POU2F1 wt Allele

Preferred Label : POU2F1 wt Allele;

NCIt synonyms : OCT1; OTF1; POU2F1; POU Domain, Class 2, Transcription Factor 1 wt Allele;

NCIt definition : Human POU2F1 wild-type allele is located in the vicinity of 1q22-q23 and is approximately 206 kb in length. This allele, which encodes POU domain, class 2, transcription factor 1 protein, is involved in the modulation of transcription by RNA polymerase II.;

NCIt note : The POU2F1gene product binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. This gene product modulates transcription transactivation by glucocorticoid receptor, androgen receptor and progestrone receptor (GeneCards).;

GenBank Accession Number : NM_002697;

Details

Origin ID

C53106;

UMLS CUI

C1706343;

OMIM relation
- Pou domain, class 2, transcription factor 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 163921801-164117000 [NCIt concept]
gene_in_chromosomal_location
- 1q22-q23 [NCIt concept]
gene_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Androgen Receptor Regulation Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Calcium Signaling in the CD4+ TCR Pathway [NCIt concept]
- FOXA1 Transcription Factor Signaling Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Developmental Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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