TAL1 wt Allele

Preferred Label : TAL1 wt Allele;

NCIt synonyms : SCL; TCL5; T-Cell Acute Lymphocytic Leukemia 1 wt Allele; BHLHA17; TAL bHLH Transcription Factor 1, Erythroid Differentiation Gene;

NCIt definition : Human TAL1 wild-type allele is located in the vicinity of 1p32 and is approximately 15 kb in length. This allele, which encodes T-cell acute lymphocytic leukemia-1 protein, is involved in the differentiation of both hematopoietic and erythroid tissues. T-cell acute leukemia is associated with the translocations t(1;7)(p32;q34) and t(1;14)(p32;q11) of the gene and the T cell receptor delta and beta loci, respectively, and is also linked to the translocation t(1;3)(p32;p21) of the gene and TCTA gene. The interchromatid fusion of the gene to the STIL gene is linked to T-cell acute leukemia.;

GenBank Accession Number : NM_003189;

Details

Origin ID

C53099;

UMLS CUI

C1704894;

OMIM relation
- T-cell acute lymphocytic leukemia 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 1p32 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- T Acute Lymphoblastic Leukemia with TAL1 Rearrangement [NCIt concept]
gene_plays_role_in_process
- DNA Binding [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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