" /> AFF3 wt Allele - CISMeF





Preferred Label : AFF3 wt Allele;

NCIt synonyms : LAF4 Gene; LAF4; AF4/FMR2 Family, Member 3 wt Allele; Lymphoid Nuclear Protein Related to AF4 Gene; LAF4 wt Allele;

NCIt definition : Human AFF3 wild-type allele is located within 2q11.2-q12 and is approximately 595 kb in length. This allele, which encodes AF4/FRM2 family member 3 protein, may play roles in both the activation of RNA polymerase II-directed transcription and the development of lymphoid tissues. Acute lymphoblastic leukemia is associated with rearrangement and fusion of this gene to the MLL gene.;

NCIt note : The AFF3 gene product is a putative transcription activator that may function in oncogenesis, and binds to double-stranded DNA in vitro (GeneCards).;

GenBank Accession Number : NM_002285;

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12/05/2024


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