" /> TLX1 wt Allele - CISMeF





Preferred Label : TLX1 wt Allele;

NCIt synonyms : Homeobox 11 Gene; T-Cell Leukemia, Homeobox 1 wt Allele; T-Cell Lymphoma 3-Associated Breakpoint Gene; TLX1; HOX11; TCL3; TCL3 Gene; HOX11 wt Allele; T-Cell Leukemia Homeobox 1 Gene; Homeo Box 11 (T-Cell Lymphoma 3-Associated Breakpoint) Gene; Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint, Homologous To Drosophila Notch) Gene; T Cell Leukemia Homeobox 1 wt Allele;

NCIt definition : Human TLX1 wild-type allele is located in the vicinity of 10q24 and is approximately 7 kb in length. This allele, which encodes T-cell leukemia homeobox protein 1, plays roles in the regulation of RNA polymerase II-mediated transcription and in the development of the spleen. T-cell acute lymphoblastic leukemia is linked to both t(10,14)(q24;q11) and t(7,10)(q35;q24) translocations, resulting in fusion of this gene to either the T-cell receptor delta or beta locus.;

NCIt note : The TLX1 gene product binds to the DNA sequence 5'-GGCGGTAAGTGG-3' (GeneCards).;

GenBank Accession Number : NM_005521;

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16/05/2024


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