Preferred Label : Gossypol;
NCIt synonyms : 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3-3'-dimethyl[2,2'-binaphthalene]-8,8'-dicarboxaldehyde; 2,2'-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]; ( /-)-Gossypol; 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde; Pogosin; Cottonseed Meal Toxin; 2,2'-bis(1,6,7-trihydroxy-4-methyl-5-isopropyl-8-aldehydonaphthalene);
NCIt related terms : (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6'7, 7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-;
NCIt definition : An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived
primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the
G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent
also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and
may act as a male contraceptive.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer.
It comes from the seed of the cotton plant (Gossypium). It blocks the growth of cells
and may kill cancer cells. Cottonseed meal toxin may also act as a male contraceptive
(a type of birth control).;
UNII : KAV15B369O;
InChIKey : QBKSWRVVCFFDOT-UHFFFAOYSA-N;
CAS number : 303-45-7;
Drug name : No Fertil; Tash 1;
Molecule name : BL-193;
Chemical formula : C30H30O8;
NSC code : 624336; 56817;
ChEBI ID : CHEBI:28584;
Codes from synonyms : 30243; NSC0056817; CDR0000045428; CDR0000644312;
Origin ID : C529;
UMLS CUI : C0018096;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
