FLI1 wt Allele

Preferred Label : FLI1 wt Allele;

NCIt synonyms : FLI1; Ewing Sarcoma Breakpoint Region 2; SIC-1; EWSR2; Friend Leukemia Virus Integration 1 wt Allele;

NCIt definition : Human FLI1 wild-type allele is located within 11q24.1-q24.3 and is approximately 118 kb in length. This allele, which encodes Friend leukemia integration 1 transcription factor protein, plays a role in the activation of transcription by RNA polymerase II. Ewing sarcoma is linked to the chromosomal translocation t(11;22)(q24;q12) of the EWSR1 gene and the FLI1 gene.;

NCIt note : The product of the FLI1 gene recognizes the DNA sequence 5'-C[CA]GGAAGT-3' (GeneCards).;

GenBank Accession Number : NM_002017;

Details

Origin ID

C52873;

UMLS CUI

C1705749;

OMIM relation
- Fli1 protooncogene, ets transcription factor [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 11: 128069199-128187521 [NCIt concept]
gene_in_chromosomal_location
- 11q24 [NCIt concept]
gene_plays_role_in_process
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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