" /> ETV4 wt Allele - CISMeF





Preferred Label : ETV4 wt Allele;

NCIt synonyms : E1A-F; PEAS3; ETS Variant 4 Gene; ETV4; E1AF; ETS Variant Gene 4 (E1A Enhancer Binding Protein, E1AF) Gene; ETS Variant Gene 4; ETS Variant Transcription Factor 4 wt Allele; PEA3;

NCIt definition : Human ETV4 wild-type allele is located in the vicinity of 17q21 and is approximately 18 kb in length. This allele, which encodes ETS translocation variant 4 protein, plays a role in the activation of transcription by RNA polymerase II. Ewing sarcoma is linked to a chromosomal translocation t(17;22)(q12;q12) of this gene with the EWSR1 gene.;

NCIt note : The product of the ETV4 gene is a transcriptional activator that binds to the enhancer of the adenovirus E1A gene, which has the core-binding sequence is 5'[AC]GGA[AT]GT-3' (Entrez Protein).;

GenBank Accession Number : NM_001986;

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12/05/2024


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