NCIt definition : Human ERG wild-type allele is located in the vicinity of 21q22.3 and is approximately
280 kb in length. This allele, which encodes transcriptional regulator ERG protein,
is involved in both the regulation of RNA polymerase II-directed transcription and
the modification of local chromatin structure. Acute myelogenous leukemia of the subtype
M2 is linked to the chromosomal translocation t(8;21)(q22;q22), which involves this
gene and the EWSR1 gene. Human myeloid leukemia is linked to the chromosomal translocation
t(16;21)(p11;q22) of this gene with the FUS gene.;