TAF4 wt Allele

Preferred Label : TAF4 wt Allele;

NCIt synonyms : TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa wt Allele; TAF2C; TAF4A; TAF2C1; TAFII130; TAF4; TAFII135;

NCIt definition : Human TAF4 wild-type allele is located in the vicinity of 20q13.33 and is approximately 91 kb in length. This allele, which encodes transcription initiation factor TFIID subunit 4 protein, plays a role in the potentiation of transcriptional activation by retinoic acid, vitamin D3 and thyroid hormone.;

NCIt note : The TAF4 gene product plays a role in the regulation of transcription factors that contain glutamine-rich sequences. Aberrant binding of the TAF4 gene product to proteins that contain expanded polyglutamine regions is involved in the pathology of several neurodegenerative disorders referred to as polyglutamine diseases, which includes Huntington disease and several forms of spinocerebellar ataxia. (Entrez Gene and OMIM);

GenBank Accession Number : NM_003185;

Details

Origin ID

C52605;

UMLS CUI

C1704907;

OMIM relation
- Taf4 rna polymerase II, tata box-binding protein-associated factor, 135-kd [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 20q13.33 [NCIt concept]
gene_plays_role_in_process
- DNA Binding [NCIt concept]
- Transcription [NCIt concept]
- Transcription Initiation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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