Enoxolone - CISMeF

Preferred Label : Enoxolone;

NCIt synonyms : 18-beta-Glycyrrhetinic Acid; beta-Glycyrrhetinic Acid; (3beta,20beta)-3-Hydroxy-11-oxoolean-12-en-29-oic Acid; 3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid;

NCIt related terms : Glycyrrhetic acid; Glycyrrhetinic acid;

NCIt definition : A pentacyclic triterpenoid aglycone metabolite of glycyrrhizin, which is a product of the plant Glycyrrhiza glabra (licorice), with potential expectorant, and gastrokinetic activities. After administration, enoxolone inhibits the metabolism of prostaglandins by both 15-hydroxyprostaglandin dehydrogenase [NAD( )] and prostaglandin reductase 2. Therefore, this agent potentiates the activity of prostaglandin E2 and F2alpha, which inhibits gastric secretion while stimulating pancreatic secretion and the secretion of intestinal and respiratory mucus, leading to increased intestinal motility and antitussive effects. Additionally, this agent inhibits 11 beta-hydroxysteroid dehydrogenase and other enzymes involved in the conversion of cortisol to cortisone in the kidneys.;

UNII : P540XA09DR;

InChIKey : MPDGHEJMBKOTSU-YKLVYJNSSA-N;

CAS number : 15301-63-0; 471-53-4;

Chemical formula : C30H46O4;

NSC code : 35347;

ChEBI ID : CHEBI:30853;

Codes from synonyms : NSC0035347; 00257;

Details

Origin ID

C526;

UMLS CUI

C0017986;

Automatic exact mappings (from CISMeF team)
- 18alpha-glycyrrhetinic acid [MeSH Supplementary Concept]
- 18beta-glycyrrhetinic acid [MeSH concept]
See also inter- (CISMeF)
- Product containing enoxolone (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Enoxolone (substance) [SNOMED CT concept]
- Product containing enoxolone (medicinal product) [SNOMED CT concept]
- enoxolone [ATC Code]
- enoxolone [Substance BNPC]
- glycyrrhetinic acid [MeSH concept]
- glycyrrhetinic acid [MeSH Descriptor]
Validated automatic mappings to BTNT
- enoxolone [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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