NCIt synonyms : CHGA; PSP; CGA; Parathyroid Secretory Protein 1 Gene; Chromogranin A (Parathyroid Secretory Protein 1) Gene; Chromogranin A wt Allele; PHES; PHE5;
NCIt definition : Human CHGA wild-type allele is located in the vicinity of 14q32 and is approximately
12 kb in length. This allele, which encodes chromogranin A protein, is involved in
the modulation of the neuroendocrine system.;
NCIt note : The CHGA gene product is a precursor to three biologically active peptides; vasostatin,
pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative
modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin,
WE-14 and GE-25, are also derived from the full-length protein. (Entrez Gene);