" /> JTB wt Allele - CISMeF





Preferred Label : JTB wt Allele;

NCIt synonyms : Jumping Translocation Breakpoint wt Allele; HJTB; BPAR; hJT; B PAR; PAR; JTB;

NCIt definition : Human JTB wild-type allele is located within 1q21 and is approximately 4 kb in length. This allele, which encodes protein JTB, is involved in jumping translocation.;

NCIt note : Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. The JTB gene (jumping translocation breakpoint) at 1q21 was identified. It is found fused with the telomeric repeats of acceptor telomeres in a case of jumping translocation. The JTB open reading frame encodes a 146-amino acid protein with a 75-amino acid extracellular domain, a 21-amino acid transmembrane domain, and a 20-amino acid intracellular domain. Jumping translocations have been reported in leukemia patients, in the Ewing family of tumors, in renal clear cell carcinoma, and in liposarcoma.;

GenBank Accession Number : NM_006694;

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01/06/2025


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