Preferred Label : GM-K562 Cell Vaccine;
NCIt definition : A cell-based vaccine comprised of K562 cells transfected with the granulocyte macrophage-colony
stimulating factor (GM-CSF) gene with potential immunopotentiating properties. Vaccination
with GM-K562 cells may stimulate the host immune system to produce an antitumoral
T-lymphocyte response, thereby inhibiting tumor growth. K562 cells are derived from
the human erythroleukemia cell line K562. GM-CSF (also known as sagramostim) expressed
by vaccine cells binds to specific cell surface receptors, modulating the proliferation
and differentiation of a variety of hematopoietic progenitor cells with some specificity
towards stimulation of leukocyte production. GM-CSF also promotes antigen presentation,
up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated
lymphokine-activated killer cell function; it may also augment host antitumoral immunity.;
Origin ID : C52190;
UMLS CUI : C1708127;
Semantic type(s)
- concept_is_in_subset
