Preferred Label : Alpha V Beta 1 Inhibitor ATN-161;
NCIt related terms : ATN-161;
NCIt definition : A small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity.
ATN-161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby
preventing integrin alpha5beta1 binding. This receptor blockade may result in inhibition
of endothelial cell-cell interactions, endothelial cell-matrix interactions, angiogenesis,
and tumor progression. Integrin alpha5beta1 is expressed on endothelial cells and
plays a crucial role in endothelial cell adhesion and migration.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. ATN-161
may prevent the spread of tumor cells and may prevent the growth of new blood vessels
that tumors need to grow. It is a type of antiangiogenesis agent.;
UNII : XW0H5LE42K;
CAS number : 262438-43-7;
Molecule name : ATN-161;
Codes from synonyms : CDR0000518301;
Origin ID : C52185;
UMLS CUI : C1706674;
Semantic type(s)
- concept_is_in_subset
