Preferred Label : Broccoli Sprout Extract;
NCIt related terms : BROCCOLI SPROUT;
NCIt definition : A cruciferous vegetable extract with potential chemopreventive activities. Broccoli
sprout extract contains a high amount of sulforaphane, a naturally occurring isothiocyanate.
Sulforaphane activates the transcription factor NF-E2-related factor 2 (Nrf2), a member
of the basic leucine zipper family, which binds to and activates antioxidant-response
elements (AREs). Subsequently, activated AREs mediate the transcription of antioxidant
enzymes (particularly glutathione-S-transferase and quinone oxidoreductase), resulting
in the detoxification of highly reactive carcinogens. AREs are cis-acting regulatory
enhancer elements found in the 5' flanking region of many phase II detoxification
enzymes.;
Alternative definition : NCI-GLOSS: A substance being studied in the prevention of cancer. Broccoli sprout
extract comes from newly sprouted broccoli. It causes cells to make enzymes that may
protect them against cancer-causing toxins in the body, and it may also block the
growth of cancer cells.;
UNII : 128UH9LOAE;
Codes from synonyms : CDR0000560643;
Origin ID : C52174;
UMLS CUI : C1707048;
Semantic type(s)
- concept_is_in_subset
