ERBB4 wt Allele

Preferred Label : ERBB4 wt Allele;

NCIt synonyms : Erb-B2 Receptor Tyrosine Kinase 4 wt Allele; V-ERB-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) Gene; HER4; ERBB-4; HER-4; NDF/Heregulin Receptor Gene; p180erbB4; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 4 Gene; ALS19;

NCIt definition : Human ERBB4 wild-type allele is located within 2q33.3-q34 and is approximately 1156 kb in length. This allele, which encodes receptor tyrosine-protein kinase erbB-4 protein, is involved in the regulation of mitogenesis and differentiation. Mutations in this gene and overexpression are associated with several cancers, including breast cancer.;

GenBank Accession Number : NM_005235;

Details

Origin ID

C52167;

UMLS CUI

C1704826;

OMIM relation
- Erb-b2 receptor tyrosine kinase 4 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Malignant Breast Neoplasm [NCIt concept]
- Solid Neoplasm [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 2: 213228793-212072321 [NCIt concept]
gene_in_chromosomal_location
- 2q33.3-q34 [NCIt concept]
gene_is_element_in_pathway
- ERBB2 Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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