IRF4 wt Allele

Preferred Label : IRF4 wt Allele;

NCIt synonyms : MUM1 Gene; LSIRF Gene; Multiple Myeloma Oncogene 1; Interferon Regulatory Factor 4 wt Allele;

NCIt definition : Human IRF4 wild-type allele is located within 6p25-p23 and is approximately 20 kb in length. This allele, which encodes interferon regulatory factor 4 protein, plays a role in lymphocyte proliferation and maturation.;

NCIt note : IRF4 is expressed as a 5 kb transcript in spleen, lymphocytes, and melanocytes and two isoforms, which differ by one glutamate residue, are produced by alternative splicing.;

GenBank Accession Number : NM_002460;

Details

Origin ID

C52132;

UMLS CUI

C1705283;

OMIM relation
- Interferon regulatory factor 4 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 6: 336760-3356193 [NCIt concept]
gene_in_chromosomal_location
- 6p25-p23 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Large B-Cell Lymphoma with IRF4 Rearrangement [NCIt concept]
gene_is_element_in_pathway
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- IFN-Beta Enhancer Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- B Cell Proliferation [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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