NCIt definition : Human RSF1 wild-type allele is located in the vicinity of 11q14.1 and is approximately
155 kb in length. This allele, which encodes remodeling and spacing factor 1 protein,
plays a role in transcriptional repression, transcriptional co-activation and nucleosome
assembly controlled by the RSF chromatin remodeling complex. The RSF1 gene is overexpressed
in high-grade ovarian serous carcinoma.;
NCIt note : The RSF gene is a putative oncogene in ovarian cancer. This gene has been shown to
be amplified in some high-grade ovarian carcinomas. Amplification or overexpression
of the RSF gene in ovarian cancer is correlated with reduced length of patient survival.;