" /> NDRG1 wt Allele - CISMeF





Preferred Label : NDRG1 wt Allele;

NCIt synonyms : RTP; CAP43; HMSNL; DRG1; CMT4D; NDR1; NMSL; PROXY1; N-myc Downstream Regulated Gene 1 wt Allele; TDD5; RIT42; GC4; NMYC Downstream-Regulated Gene 1; DRG-1; TARG1;

NCIt definition : Human NDRG1 wild-type allele is located in the vicinity of 8q24.3 and is approximately 60 kb in length. This allele, which encodes protein NDRG1, is involved in regulation of both cell differentiation and cell growth. Certain allelic variants of the NDRG1 gene cause Charcot-Marie-Tooth disease type 4D. Expression of the NDRG1 gene is up-regulated in several types of cancer such as breast cancer, colorectal carcinoma and prostate cancer.;

NCIt note : The NDRG1 gene is a putative metastasis suppressor gene. Expression of this gene is induced by cellular stress, particularly hypoxia. 17-Beta-estradiol induces down-regulation of the NDRG1 gene in human breast cancer cells.;

GenBank Accession Number : NM_006096;

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15/05/2024


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