HMGN2 wt Allele

Preferred Label : HMGN2 wt Allele;

NCIt synonyms : High-Mobility Group Nucleosomal Binding Domain 2 wt Allele; MGC5629; HMG17;

NCIt definition : Human HMGN2 wild-type allele is located in the vicinity of 1p36.1 and is approximately 4 kb in length. This allele, which encodes nonhistone chromosomal protein HMG-17 protein, plays a role in the modulation of chromatin modifications.;

NCIt note : A fragment of nonhistone chromosomal protein HMG-17 protein has been shown to localize to the nuclei of tumor cells and tumor endothelial cells in vivo; therefore, this peptide could potentially be utilized for targeting cytotoxic drugs and gene therapy vectors into tumors. Antibodies to nonhistone chromosomal protein HMG-17 protein are found in patients with many different types of autoimmune rheumatic diseases; however, these antibodies are more frequently present in patients with systemic lupus erythematosus.;

GenBank Accession Number : NM_005517;

Details

Origin ID

C52080;

UMLS CUI

C1705018;

OMIM relation
- High mobility group nucleosomal binding protein 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 26483139-26486599 [NCIt concept]
gene_in_chromosomal_location
- 1p36.1 [NCIt concept]
gene_plays_role_in_process
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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