NCIt synonyms : Deleted in Liver Cancer 1 wt Allele; ARHGAP7; STARD12; HP;
NCIt definition : Human DLC1 wild-type allele is located within 8p22 and is approximately 432 kb in
length. This allele, which encodes rho-GTPase-activating protein 7 protein, is involved
in cytoskeletal remodeling and negative regulation of cell growth. Loss of DLC1 gene
expression due to deletion and/or hypermethylation is associated with certain types
of cancer including breast cancer, hepatocellular carcinoma, gastric cancer and non-small
cell lung carcinoma.;
NCIt note : The DLC1 gene is a tumor suppressor gene.;