Gentamicin - CISMeF

Preferred Label : Gentamicin;

NCIt synonyms : Gentamycin; Gentamycin Complex;

NCIt related terms : U-Gencin; Garamycin; Genoptic;

NCIt definition : A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.;

UNII : T6Z9V48IKG;

CAS number : 1403-66-3;

Drug name : Garamicin; Garamycin; U-Gencin; Genoptic S.O.P.; Genoptic;

ChEBI ID : CHEBI:17833;

Codes from synonyms : NSC0082261;

PubMed : 15690437;

Details

Origin ID

C519;

UMLS CUI

C3854019;

Currated CISMeF NLP mapping
- Gentamicin [ICD-11 Extension code]
- Gentamicin [ICHI extension code]
- Gentamicin [SMS substance]
- Gentamicin [LOINC component]
- Gentamicin (substance) [SNOMED CT concept]
- gentamicin [MeSH concept]
- gentamicin [SNOMED Notion]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Gentamicin [LOINC component]
- Gentamicin (substance) [SNOMED CT concept]
- Product containing gentamicin (medicinal product) [SNOMED CT concept]
- gentamicin [ATC Code]
- gentamicin [ATC Code]
- gentamicin [ATC Code]
- gentamicin [ATC Code]
- gentamicin [ATC Code]
Validated automatic mappings to BTNT
- gentamicin [ATC Code]
- gentamicin [ATC Code]
- gentamicin [ATC Code]
- gentamicin [ATC Code]
- gentamicin [ATC Code]
Validated automatic mappings to NTBT
- gentamicins [MeSH Descriptor]
- gentamicins [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Gentamicin Sulfate [NCIt concept]
is_component_of_chemotherapy_regimen
- Bacitracin/Clotrimazole/Gentamicin [NCIt concept]
- Gentamicin/Piperacillin/Vancomycin [NCIt concept]
is_free_acid_or_base_form_of
- Gentamicin Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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