Preferred Label : HTR3A wt Allele;
NCIt synonyms : 5-HT3R; Serotonin-Gated Ion Channel Receptor Gene; 5-HT-3; 5-Hydroxytryptamine 3 Receptor Gene; 5-Hydroxytryptamine Receptor 3A Gene; Serotonin 5-HT-3 Receptor Gene; 5-Hydroxytryptamine (Serotonin) Receptor-3 Gene; HTR3; HTR3A; 5HT3R; 5-Hydroxytryptamine (Serotonin) Receptor 3A wt Allele; HTR3 wt Allele;
NCIt definition : Definition: Human HTR3A wild-type allele is located in the vicinity of 11q23.1 and
is approximately 15 kb in length. This allele, which encodes 5-hydroxytryptamine 3
receptor protein, plays a role in the regulation of a biogenic hormone that has diverse
functionalities.;
NCIt note : The HTR3 gene at 11q23.1 encodes Serotonin 5-HT-3 Receptor, one of the several different
receptors for serotonin (5-hydroxytryptamine, 5-HT), a biogenic hormone that functions
as a neurotransmitter, a hormone, and a mitogen. Whereas all other known serotonin
receptor subtypes are G protein-coupled receptors, this receptor is a ligand-gated
ion channel, which when activated causes fast, depolarizing responses in neurons.
It is a cation-specific, but otherwise relatively nonselective, ion channel. Two isoforms,
1/5-HT3R-AS and 2/5-HT3R-AL, are produced by alternative splicing.;
GenBank Accession Number : NM_000869;
Origin ID : C51554;
UMLS CUI : C1705233;
OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_found_in_organism
- gene_has_physical_location
- gene_in_chromosomal_location
- gene_plays_role_in_process
