PTN wt Allele - CISMeF

Preferred Label : PTN wt Allele;

NCIt synonyms : Pleiotrophin wt Allele; NEGF-1; NEGF1; HBNF; HARP; HBGF8; Pleiotrophin (Heparin Binding Growth Factor 8, Neurite Growth-Promoting Factor 1) Gene;

NCIt definition : Human PTN wild-type allele is located within 12p12.1-p11.2 and is approximately 14 kb in length. This allele, which encodes pleiotrophin protein, plays a role in mitogenesis for endothelial, epithelial, and fibroblast cells and neurite outgrowth. Further, aberrations of the gene result in allelic variants that are implicated in tumor invasion, angiogenesis, and metastasis.;

GenBank Accession Number : NM_002825;

Details

Origin ID

C51523;

UMLS CUI

C1706605;

OMIM relation
- Pleiotrophin [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 7q33-q34 [NCIt concept]
gene_is_element_in_pathway
- Syndecan-3-Mediated Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Neural Development [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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