MAS1 wt Allele

Preferred Label : MAS1 wt Allele;

NCIt synonyms : Mas Proto-Oncogene, G Protein-Coupled Receptor wt Allele; MAS; MGRA; Mas Oncogene;

NCIt definition : Human MAS1 wild-type allele is located within 6q25.3-q26 and is approximately 1 kb in length. This allele, which encodes proto-oncogene Mas protein is involved in growth regulation.;

NCIt note : Oncogene MAS encodes a novel G protein coupled receptor that was originally identified as a transforming protein when over expressed in NIH 3T3 cells. MAS has greatest sequence similarity to the substance K receptor and may encode a peptide receptor with mitogenic activity that acts through inositol lipid signaling pathways. MAS may be a receptor in a growth-regulating pathway; it seems to be involved in some aspect of angiotensin signaling.;

GenBank Accession Number : NM_002377;

Détails

Origin ID

C51469;

UMLS CUI

C1706475;

False automatic mappings
- Migraine with or without aura, susceptibility to, 1 [OMIM Phenotype]
- mA (qualifier value) [Inactive SNOMED CT concept]
OMIM relation
- Mas1 oncogene [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 6q24-q27 [NCIt concept]
gene_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Renin-Angiotensin Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

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