NCIt synonyms : Mas Proto-Oncogene, G Protein-Coupled Receptor wt Allele; MAS; MGRA; Mas Oncogene;
NCIt definition : Human MAS1 wild-type allele is located within 6q25.3-q26 and is approximately 1 kb
in length. This allele, which encodes proto-oncogene Mas protein is involved in growth
regulation.;
NCIt note : Oncogene MAS encodes a novel G protein coupled receptor that was originally identified
as a transforming protein when over expressed in NIH 3T3 cells. MAS has greatest sequence
similarity to the substance K receptor and may encode a peptide receptor with mitogenic
activity that acts through inositol lipid signaling pathways. MAS may be a receptor
in a growth-regulating pathway; it seems to be involved in some aspect of angiotensin
signaling.;