" /> SAT1 wt Allele - CISMeF





Preferred Label : SAT1 wt Allele;

NCIt synonyms : SAT wt Allele; SSAT; DC21; Spermidine/Spermine N1-Acetyltransferase 1 wt Allele; SAT; KFSDX; Spermidine/Spermine N1-Acetyltransferase Gene; SSAT-1; KFSD;

NCIt definition : Human SAT1 wild-type allele is located in the vicinity of Xp22.1 and is approximately 21 kb in length. This allele, which encodes diamine acetyltransferase 1 protein, plays a role in the regulation of polyamine intracellular concentration and polyamine transport out of cells. An allelic variant of the SAT gene is associated with keratosis follicularis spinulosa decalvans.;

NCIt note : Alternative splicing of the SAT gene produces a truncated isoform of diamine acetyltransferase 1 protein which has been suggested to contribute to tumor progression. SAT gene expression is up-regulated by non-steroidal anti-inflammatory drugs in colon cancer cells, resulting in lower intracellular levels of polyamines; this alteration in polyamine levels has been associated with decreased carcinogenesis. Transient overexpression of the SAT gene restores sensitivity of resistant human ovarian cancer cells to both N1,N12-bis(ethyl)spermine and cisplatin. Substrates for diamine acetyltransferase 1 protein include norspermidine, spermidine, spermine, N(1)acetylspermine and putrescine.;

GenBank Accession Number : NM_002970;

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09/05/2025


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