PLK2 wt Allele

Preferred Label : PLK2 wt Allele;

NCIt synonyms : SNK; SNK Gene; Polo-Like Kinase 2 (Drosophila) wt Allele; SNK wt Allele;

NCIt definition : Human PLK2 wild-type allele is located within 5q12.1-q13.2 and is approximately 6 kb in length. This allele, which encodes serine/threonine-protein kinase PLK2 protein, plays a role in cell cycle regulation. PLK2 gene expression is transcriptionally down-regulated in B-cell neoplasms.;

NCIt note : Ectopic expression of the PLK2 gene in Burkitt lymphoma cells results in apoptosis.;

GenBank Accession Number : NM_006622;

Details

Origin ID

C51320;

UMLS CUI

C1705815;

OMIM relation
- Polo-like kinase 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 5q12.1-q13.2 [NCIt concept]
gene_is_element_in_pathway
- PLK2 and PLK4 Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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