" /> NOVA2 wt Allele - CISMeF





Preferred Label : NOVA2 wt Allele;

NCIt synonyms : NOVA2; Astrocytic NOVA1-Like Gene; ANOVA Gene; Neuro-Oncologic Ventral Antigen 2 wt Allele; NOVA3; Neuro-Oncologic Ventral Antigen 3 Gene; Neurooncologic Ventral Antigen 2 Gene;

NCIt definition : Human NOVA2 wild-type allele is located in the vicinity of 19q13.3 and is approximately 34 kb in length. This allele, which encodes RNA-binding protein Nova-2, plays a role in the regulation of RNA splicing or metabolism in a specific population of developing neurons.;

NCIt note : Expressed in brain, human NOVA2 Gene encodes RNA-binding NOVA2 protein, recognized by the paraneoplastic syndrome antibody anti-Ri. NOVA1 and NOVA2 bind to similar RNA ligands with high affinity and may regulate RNA splicing. The NOVA2 KH3 domain interacts with single-stranded RNA; KH3 bound to stem loop RNA resembles a vise, with UCAC held between an invariant Gly-X-X-Gly motif and a variable loop. Tetranucleotide recognition is supported by an aliphatic alpha-helix/beta-sheet RNA-binding platform that mimics UG by making Watson-Crick-like hydrogen bonds with CA.;

GenBank Accession Number : AF083898;

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11/05/2024


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