SPAM1 wt Allele

Preferred Label : SPAM1 wt Allele;

NCIt synonyms : MGC26532; HYAL3; HYA1; PH20; SPAG15; Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) wt Allele; PH-20; HYAL1; HYAL5; HEL-S-96n;

NCIt definition : Human SPAM1 wild-type allele is located in the vicinity of 7q31.3 and is approximately 46 kb in length. This allele, which encodes hyaluronidase PH-20 protein, plays a role in hyaluronic acid induced cell signal transduction, and sperm-zona pellucida adhesion.;

NCIt note : Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis.;

GenBank Accession Number : NM_003117;

Details

Origin ID

C51228;

UMLS CUI

C1709994;

Automatic exact mappings (from CISMeF team)
- Hyaluronoglucosaminidase 1 [OMIM gene]
- Hyaluronoglucosaminidase 3 [OMIM gene]
- Sperm adhesion molecule 1 [OMIM gene]
- hyaluronidase 1 [ORDO Gene]
OMIM relation
- Sperm adhesion molecule 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 7q31.3 [NCIt concept]
gene_is_element_in_pathway
- Glycosaminoglycan Degradation Pathway [NCIt concept]
gene_plays_role_in_process
- Carbohydrate Metabolic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Fertilization [NCIt concept]
- Hydrolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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