FRK wt Allele - CISMeF

Preferred Label : FRK wt Allele;

NCIt synonyms : RAK; GTK; FYN-Related Kinase wt Allele;

NCIt definition : Human FRK wild-type allele is located within 6q21-q22.3 and is approximately 119 kb in length. This allele, which encodes tyrosine-protein kinase FRK protein, plays a role in cell cycle inhibition at the G1/S checkpoint and negative regulation of cell growth putatively via phosphorylation of perinuclear proteins.;

NCIt note : Tyrosine-protein kinase FRK protein blocks the proliferation of breast cancer cell lines.;

GenBank Accession Number : NM_002031;

Details

Origin ID

C51115;

UMLS CUI

C1705658;

OMIM relation
- Fyn-related src family tyrosine kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 6: 116488614-116369687 [NCIt concept]
gene_in_chromosomal_location
- 6q21-q22.3 [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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