NCIt definition : Human BMX wild-type allele is located in the vicinity of Xp22.2 and is approximately
92 kb in length. This allele, which encodes cytoplasmic tyrosine-protein kinase BMX
protein, is involved in signal transduction.;
NCIt note : Cytoplasmic tyrosine-protein kinase BMX protein has been shown to interact with protein
kinase Pim-1 in human prostate cancer cell lines, resulting in BMX protein activation.
This interaction is suggested to be involved in the resistance of prostate cells to
the induction of apoptosis by chemotherapeutic drugs.;