TNK2 wt Allele

Preferred Label : TNK2 wt Allele;

NCIt synonyms : Tyrosine Kinase, Non-Receptor, 2 wt Allele; ACK Gene; ACK1 Gene; ACK1; ACK1 wt Allele;

NCIt definition : Human TNK1 wild-type allele is located within 3q29 and is approximately 46 kb in length. This allele, which encodes activated CDC42 kinase 1 protein, plays a role in signal transduction.;

NCIt note : Activated Ack1 (activated CDC42 kinase 1 protein) has been shown to accelerate prostate cancer cell tumorigenesis in nude mice. This occurs in part by activated Ack1-mediated polyubiquitination/degradation of the tumor suppressor protein Wwox. Activated CDC42 kinase 1 protein may be a potential therapeutic target for prostate cancer.;

GenBank Accession Number : NM_005781;

Details

Origin ID

C51063;

UMLS CUI

C1704929;

OMIM relation
- Tyrosine kinase, nonreceptor, 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 3: 197124265-197078545 [NCIt concept]
gene_in_chromosomal_location
- 3q29 [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients