" /> AZU1 wt Allele - CISMeF





Preferred Label : AZU1 wt Allele;

NCIt synonyms : Heparin-Binding Protein Gene; CAP37 Gene; Cationic Antimicrobial Protein-37 Gene; NAZC Gene; AZU; Azurocidin 1 (Cationic Antimicrobial Protein 37) wt Allele; AZAMP Gene; Neutrophil Azurocidin Gene; Azurocidin 1 Gene; Humazur Gene; HBP Gene; Cationic Antimicrobial Protein 37 Gene;

NCIt definition : Human AZU1 wild-type allele is located in the vicinity of 19p13.3 and is approximately 7 kb in length. This allele, which encodes azurocidin protein, plays a role in the mediation of inflammatory responses and microorganism host defense.;

NCIt note : The AZU1 Gene at 19p13.3 encodes Azurocidin, an antibiotic protein of azurophil granules (specialized lysosomes of the neutrophil) with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This gene is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at the tip of the short arm of chromosome 19. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.;

GenBank Accession Number : NM_001700;

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03/05/2025


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