SIRPB1 wt Allele

Preferred Label : SIRPB1 wt Allele;

NCIt synonyms : Signal-Regulatory Protein Beta 1 wt Allele; SIRP-BETA-1; CD172b; Signal-Regulatory Protein, Beta-1 Gene;

NCIt definition : Human SIRPB1 wild-type allele is located within 20p13 and is approximately 57 kb in length. This allele, which encodes signal-regulatory protein beta-1 protein, is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.;

NCIt note : Expressed as 2 alternative isoforms in monocytes and dendritic cells, human SIRPB1 Gene (SIRPB Family/Ig Family) at 20p13 encodes N-glycosylated 398-aa 43-kDa (precursor) type I membrane protein Signal-Regulatory Protein Beta 1, a cell surface Ig-like transmembrane receptor glycoprotein containing an IgV-type domain and 2 IgC1-type domains involved in negative regulation of receptor tyrosine kinase-coupled signaling.;

GenBank Accession Number : NM_006065;

Details

Origin ID

C51032;

UMLS CUI

C1705227;

OMIM relation
- Signal regulatory protein, beta-1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 20: 1548630-1491568 [NCIt concept]
gene_in_chromosomal_location
- 20p13 [NCIt concept]
gene_plays_role_in_process
- Cell Growth [NCIt concept]
- Ligand Binding [NCIt concept]
- Myelopoiesis [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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