GSTM1 wt Allele

Preferred Label : GSTM1 wt Allele;

NCIt synonyms : GST1; Glutathione S-Transferase M1 Gene; GSTM1-1; GTM1; Glutathione S-Transferase Mu 1 wt Allele; GTH4; H-B; Liver and Fibroblast GST1 Gene; Glutathione S-Transferase, Mu-1 Gene; MU-1; MU; Glutathione Transferase, Class Mu, 1 Gene;

NCIt definition : Human GSTM1 wild-type allele is located in the vicinity of 1p13.3 and is approximately 6 kb in length. This allele, which encodes glutathione S-transferase Mu 1 protein, is involved in the conjugation of reduced glutathione with both endogenous and exogenous hydrophobic electrophilic compounds. Null mutations of the GSTM1 gene are associated with several types of human cancer such as lung, bladder, and head and neck cancers.;

GenBank Accession Number : NM_000561;

Details

Origin ID

C51026;

UMLS CUI

C1708157;

OMIM relation
- Glutathione s-transferase, mu-1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Lung Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 109942484-109948409 [NCIt concept]
gene_in_chromosomal_location
- 1p13.3 [NCIt concept]
gene_is_biomarker_type
- Disease Marker [NCIt concept]
gene_is_element_in_pathway
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Glutathione Metabolism Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
gene_plays_role_in_process
- Detoxification [NCIt concept]

Keyword's position in hierarchy(ies) :

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