TXN wt Allele - CISMeF

Preferred Label : TXN wt Allele;

NCIt synonyms : Thioredoxin wt Allele; TRX;

NCIt definition : Human TXN wild-type allele is located within 9q31 and is approximately 12 kb in length. This allele, which encodes thioredoxin protein, is involved in the reduction of numerous biological substrates via dithiol-disulfide exchange reactions. TXN gene expression is elevated in several types of cancer such as colorectal, gastric and lung cancers.;

NCIt note : TXN gene expression is induced by oxidative stress. Overexpression of this gene is associated with both increased proliferation and survival of cancer cells.;

GenBank Accession Number : NM_003329;

Details

Origin ID

C50944;

UMLS CUI

C1710337;

OMIM relation
- Thioredoxin [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 9q31 [NCIt concept]
gene_is_element_in_pathway
- Interferon Signaling Modulation Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
- TNF Receptor Family Signaling Pathway [NCIt concept]
- p38 MAPK Signaling Pathway PID [NCIt concept]
gene_plays_role_in_process
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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