" /> TDO2 wt Allele - CISMeF





Preferred Label : TDO2 wt Allele;

NCIt synonyms : Tryptophan 2,3-Dioxygenase wt Allele; TPH2;

NCIt definition : Human TDO2 wild-type allele is located within 4q31-q32 and is approximately 17 kb in length. This allele, which encodes tryptophan 2,3-dioxygenase protein, is involved in the metabolic breakdown of tryptamine and its derivatives such as tryptophan, 5-hydroxytryptophan, and serotonin.;

NCIt note : Allelic variants of the TDO2 gene have been identified that result in protein products which exhibit altered enzymatic activity. Certain polymorphisms are associated with alcoholism, attention deficit hyperactivity disorder, drug dependence and Tourette syndrome. However, the role of the TDO2 gene in addiction and mental disorders remains to be elucidated.;

GenBank Accession Number : NM_005651;

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12/05/2024


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