NCIt definition : A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal
antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects.
Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results
in a reduction of arachidonic acid conversion into prostaglandins that are involved
in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic
anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon
ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading
to a decrease in the production of aqueous humor, thereby lowering intraocular pressure.;