NCIt definition : The presence of a hole or other type of opening in the esophageal wall through which
the contents of the esophagus can pass into the mediastinum. The most common cause
of esophageal perforation is injury during a medical procedure such as esophagoscopy
or placement of a naso-gastric tube; and pathologic process such as neoplasm or gastric
reflux with ulceration. Less common causes include injuries from penetrating or blunt
trauma or injury to the esophagus during an operation on another organ, mechanical
problem such as violent retching or vomiting; ingestion of a foreign body or caustic
agents. The condition often results in infection of the mediastinum and mediastinitis.;
Alternative definition : CTCAE: A disorder characterized by a rupture in the wall of the esophagus.; FDA: The presence of a hole or other type of opening in the esophageal wall through
which the contents of the esophagus can pass into the mediastinum.;