Flucytosine - CISMeF

Preferred Label : Flucytosine;

NCIt synonyms : 4-Amino-5-fluoro-2(1H)-pyrimidinone;

NCIt related terms : Ancotil; Ro 2-9915; Ancobon; 5-FC; 5-Fluorocytosine;

NCIt definition : A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.;

Alternative definition : NCI-GLOSS: A drug that treats infections caused by fungi.;

UNII : D83282DT06;

InChIKey : XRECTZIEBJDKEO-UHFFFAOYSA-N;

CAS number : 2022-85-7;

Drug name : Ancotil; Alcobon; Ancobon;

Molecule name : Ro-2-9915;

Chemical formula : C4H4FN3O;

NSC code : 103805;

ChEBI ID : CHEBI:5100;

Codes from synonyms : NSC0103805; CDR0000045330;

Details

Origin ID

C501;

UMLS CUI

C0016278;

See also inter- (CISMeF)
- Product containing flucytosine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 5-Fluorocytosine [LOINC component]
- Flucytosine [ICD-11 Extension code]
- Flucytosine (substance) [SNOMED CT concept]
- Product containing flucytosine (medicinal product) [SNOMED CT concept]
- flucytosine [ATC Code]
- flucytosine [ATC Code]
- flucytosine [Substance BNPC]
- flucytosine [MeSH concept]
- flucytosine [SNOMED Notion]
- flucytosine [MeSH Descriptor]
Validated automatic mappings to BTNT
- flucytosine [ATC Code]
- flucytosine [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Amphotericin B/Flucytosine [NCIt concept]

Keyword's position in hierarchy(ies) :

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