" /> FOLH1 wt Allele - CISMeF





Preferred Label : FOLH1 wt Allele;

NCIt synonyms : PSMA; FOLH; GCP2; NAALAD1; PSM; FGCP; Folate Hydrolase 1 wt Allele; mGCP; NAALAdase; GCPII; Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 Gene; GIG27;

NCIt definition : Human FOLH1 wild-type allele is located in the vicinity of 11p11.2 and is approximately 62 kb in length. This allele, which encodes glutamate carboxypeptidase 2 protein, plays a role in both the uptake of folate in the intestine and the hydrolysis of N-aceylaspartylglutamate, the major neurotransmitter in the brain. This gene is overexpressed in human prostate cancer and may inhibit metastasis of this disease.;

NCIt note : In the prostate gland, androgen deprivation causes up-regulation of FOLH1 gene expression.;

GenBank Accession Number : NM_004476;

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30/04/2024


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