Thiazide Diuretic

Preferred Label : Thiazide Diuretic;

NCIt definition : Any benzothiadiazide derivative or other thiazide-like agent with diuretic and anti-hypertensive activity. Thiazide diuretics inhibit the sodium-chloride transporter in the distal tubule in the kidneys, thereby suppressing sodium and chloride reabsorption from the distal convoluted tubules (DCT) and increasing the excretion of sodium, chloride, potassium and water. In addition, thiazide diuretics decrease excretion of calcium and uric acid. These agents cause vasodilation possibly by activating calcium-activated potassium channels in vascular smooth muscle and inhibiting various carbonic anhydrases in vascular tissue.;

Details

Origin ID

C49185;

UMLS CUI

C0012802;

Automatic exact mappings (from CISMeF team)
- Diuretic thiazide [ICHI extension code]
Currated CISMeF NLP mapping
- Diuretic thiazide [ICD-11 Extension code]
- Thiazide diuretic (product) [Inactive SNOMED CT concept]
- Thiazide diuretic (substance) [SNOMED CT concept]
- diuretics, thiazide [MeSH concept]
- thiazide diuretic, nos [SNOMED Notion]
See also inter- (CISMeF)
- sodium chloride symporter inhibitors [MeSH Descriptor]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Diuretic thiazide [ICD-11 Extension code]
- Medicinal product containing thiazide and acting as diuretic agent (product) [SNOMED CT concept]
- Thiazide diuretic (product) [Inactive SNOMED CT concept]
- Thiazide diuretic (substance) [SNOMED CT concept]
- diuretics, thiazide [MeSH concept]
- thiazide diuretic, nos [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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