" /> Inosine Monophosphate Dehydrogenase Inhibitor AVN944 - CISMeF





Preferred Label : Inosine Monophosphate Dehydrogenase Inhibitor AVN944;

NCIt related terms : AVN944; AVN-944;

NCIt definition : An orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks cells from making DNA and RNA and may kill cancer cells. It is a type of inosine monophosphate dehydrogenase (IMPDH) inhibitor.;

UNII : I3NPL1V48Q;

InChIKey : GYCPCOJTCINIFZ-OXJNMPFZSA-N;

CAS number : 297730-17-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 297730-17-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AVN944;

Chemical formula : C25H27N5O5;

Codes from synonyms : CDR0000648943;

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16/05/2024


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