Preferred Label : PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector IMNN-001;
NCIt synonyms : phIL-12-005; IL-12 Plasmid Formulated With PEG-PEI-Cholesterol Lipopolymer; EGEN-001; Nanoparticle-encased IL-12 DNA Plasmid Vector;
NCIt definition : A nanoparticle-based formulation composed of a non-viral plasmid DNA vector encoding
the human pro-inflammatory cytokine interleukin-12 (IL-12) encapsulated in a biodegradable,
biocompatible lipoplex composed of polyethylene glycol (PEG), polyethylenimine (PEI),
and cholesterol, with potential immunoactivating and antineoplastic activities. Upon
intraperitoneal (IP) delivery of the PEG-PEI-cholesterol lipopolymer-encased IL-12
DNA plasmid vector IMNN-001, the lipoplex is endocytosed by nearby cells, and the
plasmid DNA is transported into the nucleus, which leads to local expresssion of IL-12.
In turn, the increased IL-12 production at the tumor site activates the immune system
by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma
(IFN-g) and promoting cytotoxic T-cell responses against tumor cells.;
Molecule name : GEN-1; IMNN 001; IMNN-001; GEN 1;
Origin ID : C49178;
UMLS CUI : C1707844;
Semantic type(s)
- UMLS correspondences (same concept)
- GEN-1 [MeSH Supplementary Concept]
- concept_is_in_subset
