Preferred Label : 11C Topotecan;
NCIt synonyms : 11C Topotecan;
NCIt definition : A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid
extracted from the Asian tree Camptotheca acuminata radiolabeled with carbon 11 (11C)
with antineoplastic and radiotracer properties. During the S phase of the cell cycle,
topotecan inhibits topoisomerase I activity by stabilizing the cleavable complex between
topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and
trigger apoptotic cell death. Quantitation of 11C topotecan accumulated in tumor tissues
by positron emission tomography (PET) may help predict responses to topotecan therapy.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of certain types of cancer,
including ovarian cancer and lung cancer. 11C topotecan is a radioactive form of the
anticancer drug topotecan. It builds up in tumor tissues and is detected by positron
emission tomography (PET). It may be used to help determine whether treatment with
topotecan will work. It is a type of topoisomerase I inhibitor.;
Codes from synonyms : CDR0000560649;
Origin ID : C49172;
UMLS CUI : C1711433;
Semantic type(s)
- concept_is_in_subset
