Alvimopan - CISMeF

Preferred Label : Alvimopan;

NCIt definition : A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.;

UNII : 677C126AET;

InChIKey : USPVLEIQIUNQGE-DBFLIVQGSA-N;

CAS number : 170098-38-1;

Drug name : Entereg;

Molecule name : LY-246376; ADL8-2698;

Chemical formula : C25H32N2O4.2H2O;

Details

Origin ID

C49096;

UMLS CUI

C1508750;

Automatic exact mappings (from CISMeF team)
- Alvimopan [ICD-11 Extension code]
- Product containing alvimopan (medicinal product) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Alvimopan (substance) [SNOMED CT concept]
- alvimopan [ATC Code]
- alvimopan [MeSH concept]
- alvimopan [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Alvimopan (substance) [SNOMED CT concept]
- Product containing alvimopan (medicinal product) [SNOMED CT concept]
- alvimopan [ATC Code]
- alvimopan [MeSH concept]
- alvimopan [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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