JNK Inhibitor CC-401

Preferred Label : JNK Inhibitor CC-401;

NCIt related terms : CC-401;

NCIt definition : A second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based on the chemistry of SP600125, another anthrapyrazolone inhibitor of JNK, CC-401 competitively binds the ATP binding site of JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of transcription factor c-Jun; decreased transcription activity of c-Jun; and a variety of cellular effects including decreased cellular proliferation.;

UNII : NOE38VQA1W;

CAS number : 395104-30-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 395104-30-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CC-401;

NCI Metathesaurus CUI : CL937289;

Details

Origin ID

C49095;

UMLS CUI

C1707079;

See also inter- (CISMeF)
- CC 401 [MeSH concept]
- CC 401 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CC 401 [MeSH concept]
- CC 401 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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