Preferred Label : Immunomodulator OHR/AVR118;
NCIt synonyms : Product R;
NCIt definition : A broad-spectrum peptide nucleic acid formulation comprised of breakdown products
of casein, peptone, RNA and serum albumin, with potential anti-inflammatory, immunomodulatory,
anti-anorectic and anti-cachexia activities. AVR118 mainly contains two peptides,
peptide A and peptide B, in approximately a 1:1 ratio: peptide A (31 a. a.) is derived
from bovine casein; peptide B (21 a. a.) is covalently linked via phosphodiester bond
to a diadenosine unit. In addition, AVR118 contains nucleosides, nucleoside diphosphates
and nucleoside monophosphates. Upon subcutaneous injection of AVR118, this agent affects
the synthesis of many pro-inflammatory chemokines and cytokines, especially monocyte
chemotactic protein-1 (MCP-1), interleukin (IL)-8, IL-1 beta, IL-6, and tumor necrosis
factor-alpha (TNF-alpha). In particular, AVR118 stimulates macrophages to produce
these mediators while in highly activated macrophages this agent inhibits their synthesis.
This way, AVR118 may prevent the excessive release of cytokines seen during chemotherapy.
Controlling the release of pro-inflammatory mediators may ultimately improve appetite
and mood, increase strength and weight gain, and decrease fatigue.;
Molecule name : AVR118;
Origin ID : C49092;
UMLS CUI : C5441997;
Currated CISMeF NLP mapping
- EOM613 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- EOM613 [MeSH Supplementary Concept]
- concept_is_in_subset
