Preferred Label : VGEFR/c-kit/PDGFR Tyrosine Kinase Inhibitor XL820;
NCIt definition : An orally bioavailable, small molecule receptor tyrosine kinase inhibitor with potential
antineoplastic activity. XL820 binds to and inhibits the receptor tyrosine kinases
for vascular endothelial growth factor (VEGF), c-kit, and platelet-derived growth
factor (PDGF). In tumor models of breast carcinomas, gliomas, and leukemia, this agent
exhibits dose-dependent growth inhibition and has been shown to cause tumor regression.;
Molecule name : XL 820; XL-820;
NCI Metathesaurus CUI : CL937288;
Origin ID : C49090;
UMLS CUI : C1710687;
Semantic type(s)
- concept_is_in_subset
