Preferred Label : Hemiasterlin Analog E7974;
NCIt synonyms : Hemiasterlin Analog 7974;
NCIt related terms : E-7974;
NCIt definition : An analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic
and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca
domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule
assembly; depolymerization of existing microtubules; inhibition of mitosis; and inhibition
of cellular proliferation. This agent may have more affinity for the beta-3 tubulin
isotype.;
UNII : 1BO0C11BSH;
CAS number : 610787-07-0;
Molecule name : E7974;
Origin ID : C49083;
UMLS CUI : C1708344;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
